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Homing markers for atherosclerosis: applications for drug delivery, gene delivery and vascular imaging

7 Mar 2001

Abstract excerpt

Endothelial dysfunction plays a major role in the pathogenesis of atherosclerosis. Pro-inflammatory cytokines such as interleukin-1 beta and tumour necrosis factor alpha activate endothelial cells changing their resting phenotype to become pro-adhesive, pro-thrombotic and pro-atherogenic. Phage display in vivo biopanning has been used to identify peptide sequences that home to diseased regions of the vessel wall...

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PMID: 11248240
DOI: 10.1016/s0014-5793(01)02191-3

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