Article
Expression and penetrance of the hereditary pancreatitis phenotype in monozygotic twins.
Gut - 1 Apr 2001
Amann S T, Gates L K, Aston C E, Pandya A, Whitcomb D C
Abstract excerpt
BACKGROUND: Hereditary pancreatitis (HP) is a rare autosomal dominant disorder with variable expression and an overall lifetime penetrance of 80%. We hypothesised that (1) monozygotic twins within similar environments would develop the typical signs of HP at a similar age, and (2) if penetrance were due to modifier genes or environment, all twin pairs would be concordant for expression of HP. AIM: Identify...
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