Article
Pseudomonas aeruginosa infection of respiratory epithelium in a cystic fibrosis xenograft model.
The Journal of infectious diseases - 15 Mar 2001
Cohn L A, Weber A, Phillips T, Lory S, Kaplan M, Smith A
Abstract excerpt
Pulmonary infection with Pseudomonas aeruginosa in patients with cystic fibrosis (CF) causes a chronic destructive bronchitis. A xenograft model was used to study the susceptibility of the CF respiratory epithelium to P. aeruginosa strain PAK and the virulence of certain mutants. Despite an early trend toward increased susceptibility, colonization of CF xenografts (ID(95), 62 colony-forming units [cfu]) was not...
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