Article
Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET.
European journal of biochemistry - 1 Mar 2001
Minakuchi M, Kakazu N, Gorrin-Rivas M J, Abe T, Copeland T D, Ueda K, Adachi Y
Abstract excerpt
SET, the translocation breakpoint-encoded protein in acute undifferentiated leukemia (AUL), is a 39-kDa nuclear phosphoprotein and has an inhibitory activity for protein phosphatase 2A (PP2A). SET is fused to a putative oncoprotein, CAN/NUP214, in AUL and is thought to play a key role in leukemogenesis by its nuclear localization, protein-protein interactions and PP2A inhibitory activity. Here, we describe the...
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