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Article

Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases.

Nature structural biology - 1 Mar 2001

Zubieta C, He X Z, Dixon R A, Noel J P

Abstract excerpt

Chalcone O-methyltransferase (ChOMT) and isoflavone O-methyltransferase (IOMT) are S-adenosyl-l-methionine (SAM) dependent plant natural product methyltransferases involved in secondary metabolism in Medicago sativa (alfalfa). Here we report the crystal structure of ChOMT in complex with the product S-adenosyl-l-homocysteine and the substrate isoliquiritigenin (4,2',4'-trihydroxychalcone) refined to 1.8 A as well...

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PMID: 11224575
DOI: 10.1038/85029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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