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Membrane-Anchored Peptide Inhibits Human Immunodeficiency Virus Entry

15 Mar 2001

Abstract excerpt

Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HIV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.

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PMID: 11222732
DOI: 10.1128/jvi.75.6.3038-3042.2001

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