Article
Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction.
The New England journal of medicine - 22 Feb 2001
Hines L M, Stampfer M J, Ma J, Gaziano J M, Ridker P M, Hankinson S E, Sacks F, Rimm E B, Hunter D J
Abstract excerpt
BACKGROUND: A polymorphism in the gene for alcohol dehydrogenase type 3 (ADH3) alters the rate of alcohol metabolism. We investigated the relation among the ADH3 polymorphism, the level of alcohol consumption, and the risk of myocardial infarction in a nested case-control study based on data from the prospective Physicians' Health Study. METHODS: We identified 396 patients with eligible newly diagnosed cases of...
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