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Article

Frequent PVT1 rearrangement and novel chimeric genes PVT1-NBEA and PVT1-WWOX occur in multiple myeloma with 8q24 abnormality.

Cancer research - 1 Oct 2012

Nagoshi Hisao, Taki Tomohiko, Hanamura Ichiro, Nitta Masakazu, Otsuki Takemi, Nishida Kazuhiro, Okuda Keiko, Sakamoto Natsumi, Kobayashi Satoru, Yamamoto-Sugitani Mio, Tsutsumi Yasuhiko, Kobayashi Tsutomu, Matsumoto Yosuke, Horiike Shigeo, Kuroda Junya, Taniwaki Masafumi

Abstract excerpt

Chromosome 8q24 rearrangements are occasionally found in multiple myeloma and are associated with tumor progression. The 8q24 rearrangements were detected by FISH in 12 of 54 patients with multiple myeloma (22.2%) and in 8 of 11 multiple myeloma cell lines (72.7%). The breakpoints of 8q24 in 10 p...

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Source

Identifiers

PMID: 22869583
DOI: 10.1158/0008-5472.CAN-12-0213

Genes

NBEA
WWOX
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22869583-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Frequent PVT1 rearrangement and novel chimeric genes PVT1-NBEA and PVT1-WWOX occur in multiple myeloma with 8q24 abnormality.PMID 22869583Read ↗

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