Inhibition of pseudorabies virus replication by a dominant-negative mutant of early protein 0 expressed in a tetracycline-regulated system.

doi:10.1016/s0378-1135(00)00301-1

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Article

Inhibition of pseudorabies virus replication by a dominant-negative mutant of early protein 0 expressed in a tetracycline-regulated system.

Veterinary microbiology - 12 Feb 2001

Tasaki T, Taharaguchi S, Kobayashi T, Yoshino S, Ono E

Abstract excerpt

Pseudorabies virus (PRV) early protein 0 (EP0) consisting of 410 amino acids is a transactivator of viral genes. A mutant consisting of amino acids 1-113 exhibits dominant-negative properties. In order to assess the antiviral potential of the EP0 mutant, Vero cells were transformed with the EP0 mutant gene expressed in a tetracycline-regulated system. The transformed cell lines showed marked resistance to PRV...

Topics

Animals
Chlorocebus aethiops
Gene Expression Regulation, Viral
Herpesvirus 1, Suid
Immediate-Early Proteins
Mutation
Plasmids
RNA, Messenger
Tetracycline
Transfection
Vero Cells
Viral Proteins
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 11165064
DOI: 10.1016/s0378-1135(00)00301-1

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