Article
The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells.
Human molecular genetics - 1 Feb 2001
Boyle S, Gilchrist S, Bridger J M, Mahy N L, Ellis J A, Bickmore W A
Abstract excerpt
To fully understand genome function, the linear genome map must be integrated with a spatial map of chromosomes in the nucleus. Distinct nuclear addresses for a few human chromosomes have been described. Previously we have demonstrated that the gene-rich human chromosome 19 is located in a more central position in the nucleus than the similarly sized, but gene-poor, chromosome 18. To determine whether these two...
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