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The contribution of uniparental disomy to congenital development defects in children born to mothers at advanced childbearing age

18 Dec 2000

Abstract excerpt

Most instances of maternal uniparental disomy (UPD) start as trisomies and, similar to the latter, show a significant increase of mean maternal age at delivery. To investigate the incidence of UPD in offspring of older mothers, we investigated two groups of patients: 1) 50 patients with unclassified developmental defects born to mothers 35 years or older at delivery were tested for UPD for all autosomes by means...

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PMID: 11146466
DOI: 10.1002/1096-8628(20001218)95:5<454::aid-ajmg9>3.0.co;2-o

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