Haptoglobins as markers of blood-CSF barrier dysfunction: the findings in normal CSF.

doi:10.1016/s0022-510x(00)00461-5

Article

Haptoglobins as markers of blood-CSF barrier dysfunction: the findings in normal CSF.

Journal of the neurological sciences - 1 Jan 2001

Chamoun V, Zeman A, Blennow K, Fredman P, Wallin A, Keir G, Giovannoni G, Thompson E J

Abstract excerpt

Cerebrospinal fluid from 39 healthy individuals showed evidence for increasing blood-CSF barrier permeability with age, and confirmed that haptoglobins are more sensitive but less predictive markers of barrier permeability than total protein. Haptoglobin (Hp) species were identified by polyacrylamide gel electrophoresis followed by immunoblotting. Hp 1-1 (35 A, 85 kDa) was detected in all (9/9) subjects who...

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Haptoglobins as markers of blood-CSF barrier dysfunction: the findings in normal CSF.

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