Article
Head and trunk in zebrafish arise via coinhibition of BMP signaling by bozozok and chordino.
Genes & development - 15 Dec 2000
Gonzalez E M, Fekany-Lee K, Carmany-Rampey A, Erter C, Topczewski J, Wright C V, Solnica-Krezel L
Abstract excerpt
Spatial variations in the levels of bone morphogenetic protein (BMP) signaling are a critical determinant of dorsoanterior-ventroposterior pattern in vertebrate embryos. Whereas BMP overexpression abolishes both head and trunk development, known single and double loss-of-function mutations in BMP inhibitors have less dramatic effects. We report that combining mutations in the zebrafish genes bozozok and chordino...
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