A simple microbiological assay for the stereospecific differentiation of alpha and beta isomers of arteether.

doi:10.1002/1099-1573(200012)14:8<644::aid-ptr669>3.0.co;2-f

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A simple microbiological assay for the stereospecific differentiation of alpha and beta isomers of arteether.

Phytotherapy research : PTR - 1 Dec 2000

Santha Kumar T R, Khanuja S P, Jain D C, Srivastava S, Bhattacharya A K, Sharma R P, Kumar S

Abstract excerpt

A new rapid bioassay has been developed which can precisely differentiate between stereospecific alpha and beta isomers of the antimalarial drug arteether. This method was developed through the disc diffusion bioactivity tests wherein semisynthetically produced alpha arteether was able to inhibit the growth of E. coli strains which are defective in DNA gyrase enzyme. The wild type E. coli with intact DNA gyrase...

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