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Article

Long-term study of a female hyper-IgM immunodeficiency.

Experimental and clinical immunogenetics - 1 Jan 2000

Kaneko H, Fukao T, Inoue R, Kasahara K, Matsui E, Kondo N

Abstract excerpt

Hyper-IgM immunodeficiency (HIM) is an immunological disorder characterized by normal or elevated serum IgM levels, and reduced serum IgG and IgA levels, due to the disruption of immunoglobulin class switching in B cells. X-linked hyper-IgM is caused by the defective expression of the CD40 ligand on activated T cells, which induces immunoglobulin class switching along with some cytokines, such as interleukin 4,...

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Source

Identifiers

PMID: 11096255
DOI: 10.1159/000019136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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