Article
Polygenic and multifactorial disease gene association in man: Lessons from AIDS.
Annual review of genetics - 1 Jan 2000
O'Brien S J, Nelson G W, Winkler C A, Smith M W
Abstract excerpt
In an age when the majority of monogenic human disease genes have been identified, a particular challenge for the coming generation of human geneticists will be resolving complex polygenic and multifactorial diseases. The tools of molecular and population genetic association have much potential as well as peril in uncovering small cryptic genetic effects in disease. We have used a candidate gene approach to...
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