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Article

Modulation of substrate specificity of the DnaK chaperone by alteration of a hydrophobic arch.

Journal of molecular biology - 1 Dec 2000

Rüdiger S, Mayer M P, Schneider-Mergener J, Bukau B

Abstract excerpt

Hsp70 chaperones assist protein folding by reversible interaction with extended hydrophobic segments of substrate polypeptides. We investigated the contribution of three structural elements of the substrate- binding cavity of the Escherichia coli homologue, DnaK, to substrate specificity by investigating mutant DnaK proteins for binding to cellulose-bound peptides. Deletion of the C-terminal subdomain...

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Source

Identifiers

PMID: 11090270
DOI: 10.1006/jmbi.2000.4193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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