A paradoxical gradient of a basal lamina-associated repellent is essential for pathfinding by the Ti1 pioneer axons in cockroach embryos.

Abstract excerpt

Perturbations of in situ axon growth with proteolytic enzymes and monoclonal antibodies were used to determine the role of gradient guidance cues in the formation of the Ti1 pioneer axon trajectory in cultured cockroach embryos. Treatment with enzymes that degrade the basal lamina indicated that this substrate contains both an elastase-sensitive proximal directing cue and a collagenase-sensitive distal directing...

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