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Article

In Vivo Transduction of Cerebellar Purkinje Cells Using Adeno-Associated Virus Vectors

1 Nov 2000

Abstract excerpt

We investigated whether adenovirus or adeno-associated virus vectors can transduce cerebellar Purkinje cells (PCs) in vivo. Mice were injected in the deep cerebellar nuclei (DCN) with lacZ-transducing adenovirus (Ad.RSV-betagal) or a recombinant AAV serotype 2 (rAAV2) vector (vTR-CMVbeta) mixed with wild-type adenovirus type 5 (Ad5). One week later, Ad.RSV-betagal transduced cells were found throughout the...

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PMID: 11082318
DOI: 10.1006/mthe.2000.0134

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