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Article

Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors

1 Aug 2000

Abstract excerpt

Our data demonstrate that vectors derived from recombinant feline immunodeficiency virus (rFIV) and adeno-associated virus type 5 (rAAV5) transduce cerebellar cells following direct injection into the cerebellar lobules of mice. Both recombinant viruses mediated gene transfer predominantly to neurons, with up to 2500 and 1500 Purkinje cells transduced for rAAV5 or rFIV-based vectors, respectively. The vectors...

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PMID: 10976941
DOI: 10.1097/00001756-200008210-00013

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