Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord.

Journal of neurochemistry - 1 Dec 2000

Malaspina A, Kaushik N, de Belleroche J

Abstract excerpt

We have recently isolated a 2.2-kb cDNA clone (1C5) from a human spinal cord cDNA library with partial identity to the 14-3-3 protein mRNA encoding the theta protein (YWHAQ). 14-3-3 protein transcripts are highly expressed in large projection neurones of the hippocampus, cerebellum, and spinal cord and have been found to be significantly up-regulated in rat motor neurones following hypoglossal nerve axotomy. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Tyrosine 3-Monooxygenase
Share to 14-3-3 Proteins
Share to Frontal Lobe

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organ Specificity

Share to Physical Chromosome Mapping

Share to Spinal Cord

Share to Tandem Repeat Sequences

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 11080204
DOI: 10.1046/j.1471-4159.2000.0752511.x

Genes

YWHAQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord.PMID 11080204Read ↗

Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arraysSemantic proximity Read ↗

Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arraysSemantic proximity Read ↗

Fine mapping of human PI 3-kinase associated p85 alpha transcripts in the YAC contig surrounding the spinal muscular atrophy gene.Semantic proximity Read ↗

Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23.Semantic proximity Read ↗

14-3-3 protein binds to the low molecular weight neurofilament (NFL) mRNA 3' UTR.Semantic proximity Read ↗

New forms of HMW MAP2 are preferentially expressed in the spinal cord.Semantic proximity Read ↗

Spinal Cord mRNA Profile in Patients with ALS: Comparison with Transgenic Mice Expressing the Human SOD-1 MutantSemantic proximity Read ↗

Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFδ/δ mouse model of amyotrophic lateral sclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.