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Article

The box C/D motif directs snoRNA 5'-cap hypermethylation.

Nucleic acids research - 15 Nov 2000

Speckmann W A, Terns R M, Terns M P

Abstract excerpt

The 5'-cap structure of most spliceosomal small nuclear RNAs (snRNAs) and certain small nucleolar RNAs (snoRNAs) undergoes hypermethylation from a 7-methylguanosine to a 2,2, 7-trimethylguanosine structure. 5'-Cap hypermethylation of snRNAs is dependent upon a conserved sequence element known as the Sm site common to most snRNAs. Here we have performed a mutational analysis of U3 and U14 to determine the...

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Identifiers

PMID: 11071934
DOI: 10.1093/nar/28.22.4467
PMCID: PMC113864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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