RuvABC-dependent double-strand breaks in dnaBts mutants require recA.

doi:10.1046/j.1365-2958.2000.02152.x

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Article

RuvABC-dependent double-strand breaks in dnaBts mutants require recA.

Molecular microbiology - 1 Nov 2000

Seigneur M, Ehrlich S D, Michel B

Abstract excerpt

Replication fork arrest can cause DNA double-strand breaks (DSBs). These DSBs are caused by the action of the Holliday junction resolvase RuvABC, indicating that they are made by resolution of Holliday junctions formed at blocked forks. In this work, we study the homologous recombination functions required for RuvABC-mediated breakage in cells deficient for the accessory replicative helicase Rep or deficient for...

Topics

Bacterial Proteins
DNA Damage
DNA Helicases
DNA Repair
DNA Replication
DNA, Bacterial
DNA-Binding Proteins
DnaB Helicases
Electrophoresis, Polyacrylamide Gel
Endodeoxyribonucleases
Escherichia coli
Escherichia coli Proteins
Mutation
Rec A Recombinases
Recombination, Genetic
SOS Response, Genetics

Source

Open in PubMed

Identifiers

PMID: 11069680
DOI: 10.1046/j.1365-2958.2000.02152.x

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