Article
Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sex.
American journal of human genetics - 1 Dec 2000
Nestadt G, Lan T, Samuels J, Riddle M, Bienvenu O J, Liang K Y, Hoehn-Saric R, Cullen B, Grados M, Beaty T H, Shugart Y Y
Abstract excerpt
Evidence from twin and family studies supports a genetic etiology for obsessive-compulsive disorder (OCD). The purpose of this study was to test whether a major gene is implicated in a proportion of families with OCD. Complex segregation analyses of 153 families (80 case and 73 control), ascertained in the Johns Hopkins OCD Family Study, provided strong evidence for a major gene. A Mendelian-dominant model, with...
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