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Article

The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development.

Cell - 29 Sept 2000

Fata J E, Kong Y Y, Li J, Sasaki T, Irie-Sasaki J, Moorehead R A, Elliott R, Scully S, Voura E B, Lacey D L, Boyle W J, Khokha R, Penninger J M

Abstract excerpt

Osteoprotegerin-ligand (OPGL) is a key osteoclast differentiation/activation factor essential for bone remodeling. We report that mice lacking OPGL or its receptor RANK fail to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Transplantation and OPGL-rescu...

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Share to Bone Remodeling
Share to Gonadal Steroid Hormones
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor Activator of Nuclear Factor-kappa B

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Source

Identifiers

PMID: 11051546
DOI: 10.1016/s0092-8674(00)00103-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11051546-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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