Article
Molecular assays for the diagnosis of minimal residual head-and-neck cancer: methods, reliability, pitfalls, and solutions.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2000
van Houten V M, Tabor M P, van den Brekel M W, Denkers F, Wishaupt R G, Kummer J A, Snow G B, Brakenhoff R H
Abstract excerpt
The prognosis of cancer patients is determined by the radicalness of treatment: residual tumor cells will grow out and develop in manifest local recurrences, regional recurrences, and distant metastases. Classical diagnostic methods such as radiology and histopathology have limited sensitivities, and only by molecular techniques can minimal residual disease be detected. In tissue samples containing the normal...
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