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Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status

1 Nov 2000

Abstract excerpt

p53 tumour-suppressor gene is involved in cell growth control, arrest and apoptosis. Nevertheless cell cycle arrest and apoptosis induction can be observed in p53-defective cells after exposure to DNA-damaging agents such as 5-fluorouracil (5-FU) suggesting the importance of alternative pathways via p53-independent mechanisms. In order to establish relationship between p53 status, cell cycle arrest, Bcl-2/Bax...

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PMID: 11044365
DOI: 10.1054/bjoc.2000.1455

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