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Article

Separable Mechanisms of Attachment and Cell Uptake during Retrovirus Infection

15 Nov 2000

Abstract excerpt

In the absence of viral envelope gene expression, cells expressing human immunodeficiency virus type 1 (HIV-1) gag and pol, accessory HIV functions, and a vector genome RNA produce and secrete large amount of noninfectious virus-like particles (VLPs) into the conditioned medium. After partial purification, such HIV-1 VLPs can be made infectious in cell-free conditions in vitro by complex formation with...

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PMID: 11044124
DOI: 10.1128/jvi.74.22.10790-10795.2000

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