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Article

Tanning as Part of the Eukaryotic SOS Response

1 Jun 2000

Abstract excerpt

We have determined that DNA damage is at least one of the signals generated by ultraviolet radiation that stimulates pigmentation (tanning) in human skin. This photoprotective response is functionally similar to the SOS response described in bacteria. Here we present evidence that DNA damage stimulates pigmentation, at least in part, through up-regulation of tyrosinase mRNA and protein levels. Furthermore, this...

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PMID: 11041364
DOI: 10.1034/j.1600-0749.13.s8.17.x

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