Article

Melatonin inhibits senescence-associated melanin pigmentation through the p53-TYR pathway in human primary melanocytes and the skin of C57BL/6J mice after UVB irradiation

2022-11-15

Abstract excerpt

<title>Abstract</title> <p>Purpose UVB exposure accelerates skin aging and age-associated pigmentation, but their relationship remains unclear. UVB induces premature senescence and melanin production within melanocytes, along with the upregulation of p53 and cellular tyrosinase (TYR). As a tumor suppressor gene, p53 can keep the genome intact by modulating cell apoptosis and growth arrest during DNA injury. It i...

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Literature Corpus work: aebc216c-ab7b-56cf-ac48-b67b41bb21bf
DOI: 10.21203/rs.3.rs-2204015/v1

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