Article
Photochemistry. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure.
Science (New York, N.Y.) - 20 Feb 2015
Premi Sanjay, Wallisch Silvia, Mano Camila M, Weiner Adam B, Bacchiocchi Antonella, Wakamatsu Kazumasa, Bechara Etelvino J H, Halaban Ruth, Douki Thierry, Brash Douglas E
Abstract excerpt
Mutations in sunlight-induced melanoma arise from cyclobutane pyrimidine dimers (CPDs), DNA photoproducts that are typically created picoseconds after an ultraviolet (UV) photon is absorbed at thymine or cytosine. We found that in melanocytes, CPDs are generated for >3 hours after exposure to UVA, a major component of the radiation in sunlight and in tanning beds. These "dark CPDs" constitute the majority of CPDs...
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