Article
Potential of gene therapy for treating osteogenesis imperfecta.
Clinical orthopaedics and related research - 1 Oct 2000
Niyibizi C, Smith P, Mi Z, Robbins P, Evans C
Abstract excerpt
Osteogenesis imperfecta is a heterogeneous group of genetic disorders that affect connective tissue integrity, with bone fragility being the major clinical feature. Most forms of osteogenesis imperfecta are the result of mutations in the genes that encode the pro alpha1 and pro alpha2 polypeptide chains of Type I collagen. Because osteogenesis imperfecta is an incurable genetic disease, cell therapy and gene...
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