Article
Functional diversity between orthologous myosins with minimal sequence diversity.
Journal of muscle research and cell motility - 1 May 2000
Canepari M, Rossi R, Pellegrino M A, Bottinelli R, Schiaffino S, Reggiani C
Abstract excerpt
To define the structural differences that are responsible for the functional diversity between orthologous sarcomeric myosins, we compared the rat and human beta/slow myosins. Functional comparison showed that rat beta/slow myosin has higher ATPase activity and moves actin filaments at higher speed in in vitro motility assay than human beta/slow myosin. Sequence analysis shows that the loop regions at the...
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