Expression of the virulence‐related Sca (Mn²⁺) permease in <i>Streptococcus gordonii</i> is regulated by a diphtheria toxin metallorepressor‐like protein ScaR

Abstract excerpt

The acquisition of transition metal ions by pathogenic bacteria is crucial to their growth and survival within the human host, however, the mechanisms of metal ion homeostasis in streptococci are unknown. The scaCBA operon in the human oral bacterium Streptococcus gordonii encodes the components of an ABC-type transporter for manganese (Mn2+). Production of substrate-binding lipoprotein ScaA was increased...

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