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Article

Cloning and expression of type II collagen mRNA: evaluation as a candidate for canine oculo-skeletal dysplasia.

Gene - 19 Sept 2000

Du F, Acland G M, Ray J

Abstract excerpt

The disease phenotype of oculo-skeletal dysplasia (OSD) detected in Labrador retrievers and Samoyeds shows a large degree of similarity with human Stickler and Kniest dysplasia. Type II collagen (COL2A1) mRNA, which is defective in a larger number of Stickler and Kniest patients, has been cloned and characterized from normal dog. The amino acid sequence of the canine type II procollagen is predicted to contain...

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PMID: 11024291
DOI: 10.1016/s0378-1119(00)00324-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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