Article
Functional importance of the coiled-coil of the Ebola virus glycoprotein.
Journal of virology - 1 Nov 2000
Watanabe S, Takada A, Watanabe T, Ito H, Kida H, Kawaoka Y
Abstract excerpt
Ebola virus contains a single glycoprotein (GP) that is responsible for receptor binding and membrane fusion and is proteolytically cleaved into disulfide-linked GP1 and GP2 subunits. The GP2 subunit possesses a coiled-coil motif, which plays an important role in the oligomerization and fusion activity of other viral GPs. To determine the functional significance of the coiled-coil motif of GP2, we examined the...
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