MR spectroscopic imaging of normal-appearing white matter in adrenoleukodystrophy.

doi:10.1007/s002470000233

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Article

MR spectroscopic imaging of normal-appearing white matter in adrenoleukodystrophy.

Pediatric radiology - 1 Sept 2000

Izquierdo M, Adamsbaum C, Benosman A, Aubourg P, Bittoun J

Abstract excerpt

BACKGROUND: Adrenoleukodystrophy (ALD) is characterised by wide phenotypic variation, and there is no marker to predict the onset of cerebral demyelination. The indications for therapeutic approaches depend largely on the onset of cerebral demyelination. OBJECTIVE: To evaluate the brain spectroscopic pattern in normal-appearing white matter (NAWM) in patients with various phenotypes of ALD to determine if these...

Topics

Adolescent
Adrenoleukodystrophy
Adult
Age Factors
Brain
Child
Choline
Data Interpretation, Statistical
Demyelinating Diseases
Female
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Middle Aged
Phenotype
Phosphocreatine
Prognosis

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Open in PubMed

Identifiers

PMID: 11009301
DOI: 10.1007/s002470000233

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