Article
A common polymorphism in methionine synthase reductase increases risk of premature coronary artery disease.
Journal of cardiovascular risk - 1 Jun 2000
Brown C A, McKinney K Q, Kaufman J S, Gravel R A, Rozen R
Abstract excerpt
BACKGROUND: Methionine synthase reductase (MTRR) catalyzes the regeneration of methylcobalamin, a cofactor of methionine synthase, an enzyme essential for maintaining adequate intracellular pools of methionine and tetrahydrofolate, as well as for maintaining homocysteine concentrations at nontoxic levels. We recently identified a common A-->G polymorphism at position 66 of the cDNA sequence of MTRR; this variant...
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