Article
Ultrastructural and molecular analysis of Bowman's layer corneal dystrophies: an epithelial origin?
Investigative ophthalmology & visual science - 1 Oct 2000
Ridgway A E, Akhtar S, Munier F L, Schorderet D F, Stewart H, Perveen R, Bonshek R E, Odenthal M T, Dixon M, Barraquer R, Escoto R, Black G C
Abstract excerpt
PURPOSE: Two mutations (R555Q and R124L) in the BIGH3 gene have been described in anterior or Bowman's layer dystrophies (CDB). The clinical, molecular, and ultrastructural findings of five families with CDB was reviewed to determine whether there is a consistent genotype:phenotype correlation. METHODS: Keratoplasty tissue from each patient was examined by light and electron microscopy (LM and EM). DNA was...
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