Article
Low-density lipoprotein receptor gene mutations in a Southeast Asian population with familial hypercholesterolemia.
Clinical genetics - 1 Aug 2000
Khoo K L, van Acker P, Defesche J C, Tan H, van de Kerkhof L, Heijnen-van Eijk S J, Kastelein J J, Deslypere J P
Abstract excerpt
The aim of this study was to detect mutations in the genes coding for the low-density lipoprotein receptor and apolipoprotein B in patients of Southeast Asian origin with clinically diagnosed familial hypercholesterolemia (FH) and to relate these findings with the observed lower incidence of coronary heart disease in this part of the world. A total of 86 unrelated patients with FH were selected on clinical...
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