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Biology of Lumbar Spine Fusion and Use of Bone Graft Substitutes: Present, Future, and Next Generation

1 Aug 2000

Abstract excerpt

Posterolateral lumbar spine arthrodesis is a commonly performed procedure, yet the biology of healing is poorly understood. Nonunion, or failure to achieve a solid bony fusion, occurs in up to 40% of patients. We first developed and validated a rabbit model to characterize the healing process by measuring macroscopic parameters, microscopic parameters, and gene expression. We found that presently available...

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Share to Bone Tissue Engineering Materials
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PMID: 10992434
DOI: 10.1089/107632700418092

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