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Article

Abnormalities of endothelial function in the pathogenesis of stroke: the importance of endothelin.

Journal of cardiovascular pharmacology - 1 Jan 2000

Volpe M, Cosentino F

Abstract excerpt

Endothelial cells play a key role in the local regulation of the vascular smooth muscle tone by producing and releasing relaxing and contracting factors. Endothelin (ET)-1, one of the most potent endogenous vasoconstrictor substances known, is produced by endothelial cells. In the cerebral vasculature ET-1 is thought to be involved in several pathological conditions, including vasospasm following subarachnoid...

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Identifiers

PMID: 10976781
DOI: 10.1097/00005344-200000002-00011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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