Increased sputum amino acid concentrations and auxotrophy of Pseudomonas aeruginosa in severe cystic fibrosis lung disease.

doi:10.1136/thorax.55.9.795

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Article

Increased sputum amino acid concentrations and auxotrophy of Pseudomonas aeruginosa in severe cystic fibrosis lung disease.

Thorax - 1 Sept 2000

Thomas S R, Ray A, Hodson M E, Pitt T L

Abstract excerpt

BACKGROUND: Pseudomonas aeruginosa may undergo a phenotypic change from the wild (prototrophic) type to an auxotrophic phenotype in the course of respiratory infection in patients with cystic fibrosis. The clinical significance of this is unclear. A study was undertaken to investigate whether the presence of auxotrophs of P aeruginosa in the sputum of patients with cystic fibrosis correlated with severity of...

Topics

Adolescent
Adult
Amino Acids
Cystic Fibrosis
Female
Forced Expiratory Volume
Humans
Male
Phenotype
Pseudomonas aeruginosa
Sputum
Vital Capacity

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PMID: 10950901
DOI: 10.1136/thorax.55.9.795
PMCID: PMC1745865

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