Article
Human mtDNA haplogroups associated with high or reduced spermatozoa motility.
American journal of human genetics - 1 Sept 2000
Ruiz-Pesini E, Lapeña A C, Díez-Sánchez C, Pérez-Martos A, Montoya J, Alvarez E, Díaz M, Urriés A, Montoro L, López-Pérez M J, Enríquez J A
Abstract excerpt
A variety of mtDNA mutations responsible for human diseases have been associated with molecular defects in the OXPHOS system. It has been proposed that mtDNA genetic alterations can also be responsible for sperm dysfunction. In addition, it was suggested that if sperm dysfunction is the main phenotypic consequence, these mutations could be fixed as stable mtDNA variants, because mtDNA is maternally inherited. To...
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