Article
[Deregulation of intracellular signal pathways in colorectal carcinoma].
Zentralblatt fur Chirurgie - 1 Jan 2000
Troppmair J, Rapp U R
Abstract excerpt
The analysis of the genetic causes of tumor development led to the identification of many genes affected in these diseases, which play a role in the control of cell proliferation and apoptosis. However, these studies also suggested that not all alterations are equal with regard to their effect on tumor growth, and they demonstrated that the deregulation of the classical cytoplasmic cascade made up by Ras-Raf-MEK...
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