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Activation of Host Cell Phosphatidylinositol 3-Kinases byTrypanosoma cruzi Infection

1 Oct 2000

Abstract excerpt

Trypanosoma cruzi, the causative agent of Chagas' disease in humans, is an intracellular protozoan parasite with the ability to invade a wide variety of mammalian cells by a unique and remarkable process in cell biology that is poorly understood. Here we present evidence suggesting a role for the host phosphatidylinositol (PI) 3-kinases during T. cruzi invasion. The PI 3-kinase inhibitor wortmannin marked...

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PMID: 10913160
DOI: 10.1074/jbc.m909440199

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