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Host Cell Signaling and Trypanosoma cruzi Invasion: Do All Roads Lead to Lysosomes?

19 Jul 2005

Abstract excerpt

Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease in humans, is capable of invading and replicating within a wide variety of nucleated mammalian cell types. Host cell invasion by infective T. cruzi trypomastigotes is governed by parasite-triggered activation of host cell signaling pathways. Recent studies highlighting a role for host cell phosphatidylinositol 3-kinases (PI3Ks) in the T. cruzi...

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PMID: 16030288
DOI: 10.1126/stke.2932005pe36

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