By-passing selection: direct screening for antibody-antigen interactions using protein arrays

Abstract excerpt

We have developed a system to identify highly specific antibody-antigen interactions by protein array screening. This removes the need for selection using animal immunisation or in vitro techniques such as phage or ribosome display. We screened an array of 27 648 human foetal brain proteins with 12 well-expressed antibody fragments that had not previously been exposed to any antigen. Four highly specific...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Advanced Biosensing Techniques and Applications
• Share to Monoclonal and Polyclonal Antibodies Research
• Share to Protein purification and stability