Article
Telomere-based neo-Darwinian selection of yeast clonal subpopulations.
Molecular & general genetics : MGG - 1 Jun 2000
Venditti S, Di Stefano G, Di Mauro E
Abstract excerpt
In Saccharomyces cerevisiae, imbalance of the genes coding for the heterochromatin components Sir3p and histone H4 (namely, overdosage of SIR3 and lack of one of the two genes coding for H4) causes modifications in telomere length and telomere sequence organization, favoring the insertion of Y' elements into a stably shortened (C1-3A)n repeat tract. We report here that the newly inserted Y' elements are unstable...
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