Article
No association of glutathione S-transferase M1 gene polymorphism with diabetic nephropathy in Japanese type 2 diabetic patients.
Renal failure - 1 Jan 2000
Fujita H, Narita T, Meguro H, Shimotomai T, Kitazato H, Kagaya E, Sugasawa H, Hanyu O, Suzuki K, Ito S
Abstract excerpt
Oxidative stress possibly contributes to the development of diabetic nephropathy. Therefore, the levels of endogenous antioxidants may be one of determinants of the susceptibility to diabetic nephropathy. Glutathione S-transferases (GSTs) can work as one of endogenous antioxidants to protect cells from oxidative stress. The M1 member of GST mu class (GSTM1) is polymorphic and only expressed in 55-60% of...
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